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KMID : 0363620110320060054
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Journal of Korean Oriental Medicine
2011 Volume.32 No. 6 p.54 ~ p.66
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Experimental Studies on the Antidiarrheal Effects of Anjang-san
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Oh Seung-Whan
Ryu Bong-Ha
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Abstract
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Objectives: The purpose of the present study was to investigate the antidiarrheal effects of Anjang-san in mice and rats.
Methods: We measured the content of condensed tannin in Anjang-san extract, and observed the effects of Anjang-san on the small intestinal and colonic transport of mice, as well as on mice models of diarrhea induced by castor oil and MgSO₄, and on rat models of castor oil-induced enteropooling.
Results: Anjang-san showed significant inhibitory effects on abnormally increased small intestinal transit induced by pyridostigmine and neostigmine, and inhibitory effects on large intestinal transit. Anjang-san also exhibited antidiarrheal effects on diarrhea induced by MgSO₄, and inhibitory effects on castor oil-induced enteropooling. Anjang-san also improved castor oil-induced diarrhea based on simple numbers without statistical significance.
Conclusion: These results demonstrate that Anjang-san has significant antidiarrheal properties and attests to its possible utility in functional diarrheas, irritable bowel syndrome and other gastrointestinal disorders based upon further studies.
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KEYWORD
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Anjang-san, antidiarrheal, diarrhea
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